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Selin Co, the largest lake situated on the central Tibetan Plateau (TP) and lying in the transitional zone between the Indian Summer Monsoon and the Westerlies, is an ideal site to investigate the region's paleoclimatic evolution since the Late Pleistocene. In this study, we present a high-resolution geochemical and mineralogical record retrieved from a 585-cm core in Selin Co covering the last 13 cal kyr BP based on a robust AMS C-14-determined chronology with a reservoir effect calibration. Various proxies, such as the mean grain size, Ti, Ca, Rb/Sr, total inorganic carbon (TIC) and total organic carbon (TOC), showed that the period from 12.9 to 11 cal kyr BP was characterized by stronger runoff, lower salinity and a higher lake level, indicating a cold and wet period. A Younger Dryas event likely occurred during the period 12.8-12.5 cal kyr BP, and all proxies exhibited a sharp change from 11.2 to 10.8 cal kyr BP that showed the termination of the cold/wet period followed by the onset of the Holocene. From 11 to 8 cal kyr BP, a transition from a drier to a relatively wet period occurred. An abrupt decrease in the TOC record in Selin Co at 9.2 cal kyr BP suggested a cold event. During the period 8 to 4 cal kyr BP, a relatively warm and dry climate was observed. At 4 cal kyr BP, all proxies indicated a low lake level and hence a dry event in Selin Co. A stable low lake level after 4 cal kyr BP was observed until an increase beginning at 800 cal yr BP. A significant lake level rise has coincided with the strengthening Westerlies during recent decades. These climatic variabilities in the Selin Co area since the Late Glacial have primarily been driven by temperature-induced evaporation in addition to precipitation via monsoonal circulation and/or westerly jets.